Platinum in PDB 8h7c: Crystal Structure of A De Novo Enzyme, Ferric Enterobactin Esterase Syn-F4 (K4T) - Pt Derivative

All present enzymatic activity of Crystal Structure of A De Novo Enzyme, Ferric Enterobactin Esterase Syn-F4 (K4T) - Pt Derivative:
3.1.1.108;

The structure of Crystal Structure of A De Novo Enzyme, Ferric Enterobactin Esterase Syn-F4 (K4T) - Pt Derivative, PDB code: 8h7c was solved by K.Kurihara, K.Umezawa, A.E.Donnelly, M.H.Hecht, R.Arai, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	50.00 / 2.15
Space group	C 2 2 21
Cell size a, b, c (Å), α, β, γ (°)	47.986, 61.468, 128.991, 90, 90, 90
R / Rfree (%)	23.3 / 27

The structure of Crystal Structure of A De Novo Enzyme, Ferric Enterobactin Esterase Syn-F4 (K4T) - Pt Derivative also contains other interesting chemical elements:

Chlorine

(Cl)

5 atoms

The binding sites of Platinum atom in the Crystal Structure of A De Novo Enzyme, Ferric Enterobactin Esterase Syn-F4 (K4T) - Pt Derivative (pdb code 8h7c). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 2 binding sites of Platinum where determined in the Crystal Structure of A De Novo Enzyme, Ferric Enterobactin Esterase Syn-F4 (K4T) - Pt Derivative, PDB code: 8h7c:
Jump to Platinum binding site number: 1; 2;

Platinum binding site 1 out of 2 in the Crystal Structure of A De Novo Enzyme, Ferric Enterobactin Esterase Syn-F4 (K4T) - Pt Derivative


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Crystal Structure of A De Novo Enzyme, Ferric Enterobactin Esterase Syn-F4 (K4T) - Pt Derivative within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt201 b:30.7 occ:0.90 ND1 A:HIS31 2.4 18.1 1.0 CL A:CL202 2.6 43.9 1.0 OXT A:ACT203 3.2 31.7 1.0 CG A:HIS31 3.3 17.4 1.0 CE1 A:HIS31 3.3 17.6 1.0 C A:ACT203 3.4 31.7 1.0 CB A:HIS31 3.5 17.4 1.0 CH3 A:ACT203 3.5 30.2 1.0 O A:ACT203 4.1 30.5 1.0 CA A:HIS31 4.4 17.6 1.0 CD2 A:HIS31 4.4 17.1 1.0 NE2 A:HIS31 4.4 17.1 1.0 O A:HIS31 4.7 17.6 1.0 C A:HIS31 4.9 18.3 1.0

Platinum binding site 2 out of 2 in the Crystal Structure of A De Novo Enzyme, Ferric Enterobactin Esterase Syn-F4 (K4T) - Pt Derivative


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Crystal Structure of A De Novo Enzyme, Ferric Enterobactin Esterase Syn-F4 (K4T) - Pt Derivative within 5.0Å range: probe atom residue distance (Å) B Occ B:Pt201 b:15.5 occ:0.30 PT B:PC4201 0.0 15.5 0.3 CL4 B:PC4201 2.4 15.5 0.3 CL1 B:PC4201 2.4 15.3 0.3 CL2 B:PC4201 2.4 15.4 0.3 CL3 B:PC4201 2.4 15.4 0.3 ND1 B:HIS46 4.1 100.8 1.0 CE1 B:HIS46 4.3 99.8 1.0 CG B:HIS46 4.6 97.7 1.0 NE2 B:HIS46 4.7 99.7 1.0 CD2 B:HIS46 4.9 98.2 1.0

K.Kurihara, K.Umezawa, A.E.Donnelly, B.Sperling, G.Liao, M.H.Hecht, R.Arai. Crystal Structure and Activity of A De Novo Enzyme, Ferric Enterobactin Esterase Syn-F4. Proc.Natl.Acad.Sci.Usa V. 120 81120 2023.
ISSN: ESSN 1091-6490
PubMed: 37695900
DOI: 10.1073/PNAS.2218281120