Platinum in PDB 9h49: Crystal Structure of the Adduct Between Human Serum Transferrin (Apo- Form) and Cisplatin

The structure of Crystal Structure of the Adduct Between Human Serum Transferrin (Apo- Form) and Cisplatin, PDB code: 9h49 was solved by R.Troisi, F.Galardo, G.Ferraro, F.Sica, A.Merlino, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	80.84 / 3.52
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	88.184, 103.68, 200.283, 90, 90, 90
R / Rfree (%)	23.1 / 24.9

The binding sites of Platinum atom in the Crystal Structure of the Adduct Between Human Serum Transferrin (Apo- Form) and Cisplatin (pdb code 9h49). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 4 binding sites of Platinum where determined in the Crystal Structure of the Adduct Between Human Serum Transferrin (Apo- Form) and Cisplatin, PDB code: 9h49:
Jump to Platinum binding site number: 1; 2; 3; 4;

Platinum binding site 1 out of 4 in the Crystal Structure of the Adduct Between Human Serum Transferrin (Apo- Form) and Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Crystal Structure of the Adduct Between Human Serum Transferrin (Apo- Form) and Cisplatin within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt704 b:275.5 occ:0.80 N A:NH3705 2.1 263.1 0.8 O A:HOH802 2.1 236.9 0.8 N A:NH3706 2.1 243.4 0.8 SD A:MET256 2.2 210.1 1.0 CG A:MET256 3.2 191.6 1.0 CB A:MET256 3.5 172.6 1.0 CE A:MET256 3.7 192.8 1.0 CA A:MET256 4.6 156.3 1.0

Platinum binding site 2 out of 4 in the Crystal Structure of the Adduct Between Human Serum Transferrin (Apo- Form) and Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Crystal Structure of the Adduct Between Human Serum Transferrin (Apo- Form) and Cisplatin within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt707 b:289.1 occ:0.80 O A:HOH801 2.1 255.5 0.8 N A:NH3708 2.1 263.1 0.8 N A:NH3709 2.1 264.9 0.8 SD A:MET499 2.2 217.9 1.0 CG A:MET499 3.5 197.4 1.0 CE A:MET499 3.7 207.5 1.0 CB A:MET499 4.1 193.8 1.0 OE1 A:GLU526 4.4 196.6 1.0 OH A:TYR514 4.5 231.7 1.0 O A:MET499 4.8 196.6 1.0 OE2 A:GLU526 4.8 192.1 1.0 CZ A:TYR514 4.8 226.7 1.0 CE1 A:TYR514 4.9 225.8 1.0

Platinum binding site 3 out of 4 in the Crystal Structure of the Adduct Between Human Serum Transferrin (Apo- Form) and Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 3 of Crystal Structure of the Adduct Between Human Serum Transferrin (Apo- Form) and Cisplatin within 5.0Å range: probe atom residue distance (Å) B Occ B:Pt704 b:245.2 occ:0.65 N B:NH3706 2.1 235.0 0.7 N B:NH3705 2.1 224.7 0.7 O B:HOH802 2.1 214.4 0.7 SD B:MET256 2.2 205.4 1.0 CG B:MET256 2.9 185.0 1.0 CB B:MET256 3.2 170.4 1.0 CE B:MET256 3.5 196.8 1.0 CA B:MET256 4.8 155.5 1.0

Platinum binding site 4 out of 4 in the Crystal Structure of the Adduct Between Human Serum Transferrin (Apo- Form) and Cisplatin


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 4 of Crystal Structure of the Adduct Between Human Serum Transferrin (Apo- Form) and Cisplatin within 5.0Å range: probe atom residue distance (Å) B Occ B:Pt707 b:203.1 occ:0.65 O B:HOH803 2.1 211.1 0.7 N B:NH3708 2.1 209.9 0.7 N B:NH3709 2.1 166.6 0.7 SD B:MET499 2.2 211.4 1.0 CB B:MET499 3.3 200.8 1.0 CG B:MET499 3.4 205.3 1.0 CE B:MET499 3.7 204.8 1.0 O B:MET499 3.8 190.4 1.0 CA B:MET499 4.6 195.0 1.0 C B:MET499 4.6 188.4 1.0 OH B:TYR514 5.0 200.2 1.0

R.Troisi, F.Galardo, G.Ferraro, F.Sica, A.Merlino. Crystal Structure of the Adduct Between Human Serum Transferrin (Apo Form) and Cisplatin To Be Published.