Platinum in PDB 8bwa: Crystal Structure of Human Twisted Gastrulation Protein Homolog 1 (TWSG1) in Complex with Platinum

The structure of Crystal Structure of Human Twisted Gastrulation Protein Homolog 1 (TWSG1) in Complex with Platinum, PDB code: 8bwa was solved by T.Malinauskas, A.F.Rudolf, G.Moore, H.Eggington, H.Belnoue-Davis, K.Elomari, R.E.Woolley, S.C.Griffiths, R.Duman, A.Wagner, S.J.Leedham, C.Baldock, H.Ashe, C.Siebold, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	49.22 / 3.61
Space group	P 65 2 2
Cell size a, b, c (Å), α, β, γ (°)	98.43, 98.43, 188.16, 90, 90, 120
R / Rfree (%)	33.9 / 39

The binding sites of Platinum atom in the Crystal Structure of Human Twisted Gastrulation Protein Homolog 1 (TWSG1) in Complex with Platinum (pdb code 8bwa). This binding sites where shown within 5.0 Angstroms radius around Platinum atom.
In total 7 binding sites of Platinum where determined in the Crystal Structure of Human Twisted Gastrulation Protein Homolog 1 (TWSG1) in Complex with Platinum, PDB code: 8bwa:
Jump to Platinum binding site number: 1; 2; 3; 4; 5; 6; 7;

Platinum binding site 1 out of 7 in the Crystal Structure of Human Twisted Gastrulation Protein Homolog 1 (TWSG1) in Complex with Platinum


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 1 of Crystal Structure of Human Twisted Gastrulation Protein Homolog 1 (TWSG1) in Complex with Platinum within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt301 b:331.2 occ:1.00 HG2 A:MET60 2.1 221.1 1.0 SD A:MET60 2.3 231.0 1.0 HG3 A:MET60 2.3 221.1 1.0 CG A:MET60 2.3 239.5 1.0 HE3 A:MET60 3.1 221.2 1.0 CE A:MET60 3.3 235.7 1.0 HB3 A:TRP67 3.7 215.5 1.0 HE1 A:MET60 3.8 221.2 1.0 CB A:MET60 3.8 242.3 1.0 HD1 A:TRP67 3.9 222.0 1.0 CD1 A:TRP67 3.9 231.4 1.0 CG A:TRP67 3.9 240.6 1.0 HB2 A:TRP67 4.0 215.5 1.0 HE2 A:MET60 4.0 221.2 1.0 CB A:TRP67 4.1 253.6 1.0 HB3 A:MET60 4.2 226.8 1.0 HB2 A:MET60 4.3 226.8 1.0 O A:MET60 4.3 276.3 1.0 NE1 A:TRP67 4.5 225.2 1.0 CD2 A:TRP67 4.6 240.4 1.0 C A:MET60 4.6 265.5 1.0 CA A:MET60 4.7 256.8 1.0 HA A:MET60 4.7 220.5 1.0 O A:GLY64 4.8 241.1 1.0 HE1 A:TRP67 4.9 222.3 1.0 CE2 A:TRP67 4.9 229.0 1.0

Platinum binding site 2 out of 7 in the Crystal Structure of Human Twisted Gastrulation Protein Homolog 1 (TWSG1) in Complex with Platinum


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 2 of Crystal Structure of Human Twisted Gastrulation Protein Homolog 1 (TWSG1) in Complex with Platinum within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt302 b:356.4 occ:1.00 SD A:MET166 2.2 259.3 1.0 HG2 A:MET166 2.6 262.6 1.0 CG A:MET166 2.7 254.7 1.0 HG3 A:MET166 2.8 262.6 1.0 HG3 A:PRO122 3.2 259.9 1.0 HE2 A:MET166 3.3 248.1 1.0 CE A:MET166 3.4 265.2 1.0 HE1 A:MET166 3.8 248.1 1.0 HA A:PRO122 4.0 240.2 1.0 CG A:PRO122 4.1 248.4 1.0 HB3 A:PRO122 4.2 246.4 1.0 HE3 A:MET166 4.2 248.1 1.0 CB A:MET166 4.2 249.5 1.0 HD3 A:PRO122 4.4 251.0 1.0 HB3 A:MET166 4.5 248.3 1.0 CB A:PRO122 4.5 246.8 1.0 CA A:PRO122 4.6 242.0 1.0 HB2 A:MET166 4.6 248.3 1.0 CD A:PRO122 4.7 242.8 1.0 HG2 A:PRO122 4.7 259.9 1.0 N A:PRO122 4.8 239.4 1.0 HA A:MET166 5.0 243.2 1.0

Platinum binding site 3 out of 7 in the Crystal Structure of Human Twisted Gastrulation Protein Homolog 1 (TWSG1) in Complex with Platinum


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 3 of Crystal Structure of Human Twisted Gastrulation Protein Homolog 1 (TWSG1) in Complex with Platinum within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt303 b:316.9 occ:1.00 SD A:MET219 2.2 238.6 1.0 HB3 A:MET219 3.2 210.0 1.0 HB2 A:MET219 3.4 210.0 1.0 CG A:MET219 3.5 229.2 1.0 CB A:MET219 3.5 226.7 1.0 CE A:MET219 3.8 230.2 1.0 HE1 A:MET219 3.9 220.8 1.0 HG2 A:MET219 4.1 214.0 1.0 HG3 A:MET219 4.1 214.0 1.0 HE2 A:MET219 4.1 220.8 1.0 HE3 A:MET219 4.5 220.8 1.0

Platinum binding site 4 out of 7 in the Crystal Structure of Human Twisted Gastrulation Protein Homolog 1 (TWSG1) in Complex with Platinum


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 4 of Crystal Structure of Human Twisted Gastrulation Protein Homolog 1 (TWSG1) in Complex with Platinum within 5.0Å range: probe atom residue distance (Å) B Occ A:Pt304 b:340.5 occ:1.00 SD A:MET222 2.2 243.8 1.0 HG2 A:MET222 2.8 204.3 1.0 CG A:MET222 3.0 237.9 1.0 HB3 A:MET222 3.0 207.1 1.0 HE2 A:MET222 3.1 231.3 1.0 CE A:MET222 3.2 245.0 1.0 CB A:MET222 3.5 233.6 1.0 HE1 A:MET222 3.6 231.3 1.0 HG3 A:MET222 3.9 204.3 1.0 HB2 A:MET222 3.9 207.1 1.0 HE3 A:MET222 4.0 231.3 1.0 HB A:THR225 4.4 211.6 1.0 HG21 A:THR225 4.5 217.2 1.0 HG1 A:THR225 4.6 192.7 1.0 HA A:MET222 4.7 211.2 1.0 CA A:MET222 4.8 230.3 1.0

Platinum binding site 5 out of 7 in the Crystal Structure of Human Twisted Gastrulation Protein Homolog 1 (TWSG1) in Complex with Platinum


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 5 of Crystal Structure of Human Twisted Gastrulation Protein Homolog 1 (TWSG1) in Complex with Platinum within 5.0Å range: probe atom residue distance (Å) B Occ B:Pt301 b:369.8 occ:1.00 SD B:MET222 2.2 267.3 1.0 HB3 B:MET222 2.6 224.4 1.0 CG B:MET222 3.0 257.2 1.0 HG2 B:MET222 3.0 221.6 1.0 CB B:MET222 3.2 248.9 1.0 HB2 B:MET222 3.6 224.4 1.0 CE B:MET222 3.6 269.6 1.0 HE3 B:MET222 3.6 248.6 1.0 HB B:THR225 3.8 228.9 1.0 HE1 B:MET222 3.9 248.6 1.0 HG3 B:MET222 3.9 221.6 1.0 HG21 B:THR225 4.1 234.5 1.0 HG1 B:THR225 4.2 209.9 1.0 HE2 B:MET222 4.4 248.6 1.0 CA B:MET222 4.5 236.4 1.0 HA B:MET222 4.5 228.4 1.0 CB B:THR225 4.5 239.3 1.0 CG2 B:THR225 4.7 248.2 1.0 OG1 B:THR225 4.8 229.5 1.0 HG22 B:THR225 4.9 234.5 1.0 O B:MET222 4.9 221.7 1.0

Platinum binding site 6 out of 7 in the Crystal Structure of Human Twisted Gastrulation Protein Homolog 1 (TWSG1) in Complex with Platinum


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 6 of Crystal Structure of Human Twisted Gastrulation Protein Homolog 1 (TWSG1) in Complex with Platinum within 5.0Å range: probe atom residue distance (Å) B Occ B:Pt302 b:372.3 occ:1.00 HG2 B:MET166 2.1 279.9 1.0 SD B:MET166 2.3 305.3 1.0 CG B:MET166 2.3 289.9 1.0 HG3 B:MET166 2.4 279.9 1.0 HG3 B:PRO122 3.3 277.2 1.0 HE2 B:MET166 3.3 265.4 1.0 CE B:MET166 3.5 293.8 1.0 HA B:PRO122 3.7 257.4 1.0 CB B:MET166 3.8 285.7 1.0 HB3 B:PRO122 3.9 263.7 1.0 HE1 B:MET166 4.0 265.4 1.0 HB3 B:MET166 4.1 265.6 1.0 CG B:PRO122 4.2 286.3 1.0 HE3 B:MET166 4.2 265.4 1.0 HB2 B:MET166 4.3 265.6 1.0 CB B:PRO122 4.3 278.6 1.0 CA B:PRO122 4.4 278.9 1.0 HA B:MET166 4.5 260.5 1.0 O B:HIS165 4.6 272.2 1.0 HD3 B:PRO122 4.7 268.3 1.0 CA B:MET166 4.7 279.7 1.0 N B:PRO122 4.7 282.4 1.0 CD B:PRO122 4.8 286.2 1.0 HG2 B:PRO122 4.9 277.2 1.0

Platinum binding site 7 out of 7 in the Crystal Structure of Human Twisted Gastrulation Protein Homolog 1 (TWSG1) in Complex with Platinum


Mono view


Stereo pair view

A full contact list of Platinum with other atoms in the Pt binding site number 7 of Crystal Structure of Human Twisted Gastrulation Protein Homolog 1 (TWSG1) in Complex with Platinum within 5.0Å range: probe atom residue distance (Å) B Occ B:Pt303 b:340.8 occ:1.00 SD B:MET219 2.2 261.2 1.0 CE B:MET219 3.3 263.5 1.0 HE1 B:MET219 3.3 238.1 1.0 HE2 B:MET219 3.5 238.1 1.0 HB2 B:MET219 3.5 227.3 1.0 CG B:MET219 3.5 251.8 1.0 HG3 B:MET219 3.7 231.3 1.0 CB B:MET219 3.9 249.7 1.0 HB3 B:MET219 4.0 227.3 1.0 HD21 B:ASN117 4.1 248.6 1.0 HE3 B:MET219 4.1 238.1 1.0 HB2 B:ASN117 4.3 231.6 1.0 HG2 B:MET219 4.3 231.3 1.0 OD2 B:ASP173 4.4 262.7 1.0 OD1 B:ASP173 4.6 255.0 1.0 ND2 B:ASN117 4.7 263.8 1.0 CG B:ASP173 4.8 255.8 1.0

T.Malinauskas, G.Moore, A.F.Rudolf, H.Eggington, H.L.Belnoue-Davis, K.El Omari, S.C.Griffiths, R.E.Woolley, R.Duman, A.Wagner, S.J.Leedham, C.Baldock, H.L.Ashe, C.Siebold. Molecular Mechanism of Bmp Signal Control By Twisted Gastrulation. Nat Commun V. 15 4976 2024.
ISSN: ESSN 2041-1723
PubMed: 38862520
DOI: 10.1038/S41467-024-49065-8